Nellie Connally and Jackie both stated that the first shot hit both men, referencing when JBC cried out Oh No No No, which Gov Connally stated he cried out when he was hit.
Neither Nellie Connally nor Jackie Kennedy said that the first shot hit both men. Jackie seemed to recall that JFK reacted to the first shot but it is not clear. She said her attention was drawn by Gov. Connally shouting. She did not say Connally had been hit.
The eyewitnesses state JFK reacted to the first shot.
That is a bit of an understatement.
Every witness who observed JFK's reaction to the first shot said he reacted visibly in ways that are not seen until after z223. They recalled things he is not seen doing before disappearing behind the Stemmons sign: moving left, bringing his hands up to his face/neck, pretending to duck etc. When you combine that evidence with the photographic evidence and the absence of any reliable evidence of a missed first shot, let alone any reasonable explanation of how he could have missed the entire vehicle from above at less than 60 yards, there is no reason at all to conclude that the first shot did not hit JFK. But there is no evidence at all that it hit Gov. Connally in the back/armpit and fairly cogent evidence (from the Connally's themselves) that it did not.
A large number of them also stated there was only two shots.
It depends on what you mean by "large". It is certainly a very small proportion of the witnesses who heard only two shots - less than 10%. As tabulated for the HSCA of 178 witnesses: 17 recalled hearing two; 7 said they heard two or three shots; 132 reported hearing exactly three shots; 6 people said they heard four shots; and 9 said they were not sure how many shots they heard. A further 7 bystanders reported hearing 1, 5, 6, or 8 shots. (D. M. Green, “Analysis of Earwitness Reports Relating to the Assassination of President John F. Kennedy”, Report No. 4034, 8 HSCA 128 at 142).