It seems Talbot's "white mice" reference/metaphor was about this (fasten your seat belt, it's going to be rough). This is from his book on Dulles, "The Devil's Chessboard", pg. 135.
"But even the sophisticated Mary [Bancroft] found herself unnerved by one of her conversations with Dulles. She had observed that despite his cunning reputation, Allen always seemed so 'open and trusting' even with people about whom he clearly harbored suspicions or whom he 'actually had the goods on.' As he listened to Mary, Dulles grinned. 'I like to watch the little mice sniffing at the cheese just before they venture into their little trap', he told her. 'I like to see their expressions when it snaps shut, breaking their little necks.'
Elsewhere in the book he refers again to what he calls "little mice" - people that were covert operatives, agents and assets (many unwitting) - that he says Dulles used and discarded (the "little traps") during WWII and the Cold War.
Since Talbot believes Dulles was the mastermind behind the assassination, he argues that the Paines were some of these "mice" that he used/trapped to help kill JFK and frame Oswald.